MovDisordV3, Main, Exploration, bibRecord, 004C10

Variations in the monoamine oxidase B lpar;MAOB) gene are associated with Parkinson's disease

Identifieur interne : 004C10 ( Main/Exploration ); précédent : 004C09; suivant : 004C11

Variations in the monoamine oxidase B lpar;MAOB) gene are associated with Parkinson's disease

Auteurs : George D. Mellick [Australie] ; Daniel D. Buchanan [Australie] ; Sally J. Mccann [Australie] ; Kristy M. James [Australie] ; Anthony G. Johnson [Australie] ; Darren R. Davis [Australie] ; Nanay Liyou [Australie] ; Daniel Chan [Australie] ; David G. Le Couteur [Australie]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-03.

RBID : ISTEX:FDD5114F53B156A6821233554272A90BD578696A

Descripteurs français

Pascal (Inist)
- Amine oxidase (flavin-containing), Facteur risque, Gène, Homme, Parkinson maladie, Réaction chaîne polymérase.
Wicri :
- topic : Génétique, Homme.

English descriptors

KwdEn :
- Aged, Amine oxidase (flavin-containing), Analysis of Variance, Case-Control Studies, Cohort Studies, Dinucleotide Repeats, Female, Gene, Gene Dosage, Genetics, Human, Humans, Male, Monoamine Oxidase (genetics), Monoamine oxidase B, New South Wales (epidemiology), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymerase Chain Reaction, Polymerase chain reaction, Polymorphism, Genetic (genetics), Queensland (epidemiology), Risk factor, Statistics as Topic.
MESH :
- chemical , genetics : Monoamine Oxidase.
- geographic , epidemiology : New South Wales, Queensland.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease, Polymorphism, Genetic.
- Aged, Analysis of Variance, Case-Control Studies, Cohort Studies, Dinucleotide Repeats, Female, Gene Dosage, Humans, Male, Polymerase Chain Reaction, Statistics as Topic.

Abstract

The monoamine oxidase B gene (MAOB; Xp15.21‐4) is a candidate gene for Parkinson's disease (PD) given its role in dopamine metabolism and its possible role in the activation of neurotoxins. The association of MAOB polymorphisms (a [GT] repeat allelic variation in intron 2 and an A–G transition in intron 13) with Parkinson's disease (PD) was studied in an Australian cohort of 204 (male:female ratio 1.60) people with PD and 285 (male:female ratio 1.64) age‐ and gender‐matched control subjects. Genomic DNA was extracted from venous blood and polymerase chain reaction was used to amplify the appropriate regions of the MAOB gene. The length of each (GT) repeat sequence was determined by 5% polyacrylamide denaturing gel electrophoresis and a DNA fragment analyzer, while the G–A genotype was determined using 2% agarose gel electrophoresis. The G–A polymorphism showed no association with PD (odds ratio [OR] = 0.80; p = 0.51; 95% confidence interval [CI] = 0.42–1.53). There was a significant difference in allele frequencies of the (GT) repeat allelic variation between patients and control subjects (χ2 = 20.09; p <0.01). After statistical adjustment for potential confounders using a logistic regression analysis, the (GT) repeat alleles ⩾188 base pairs in the intron 2 marker of the MAOB gene were significantly associated with PD (OR = 4.60; p <0.00005; 95% CI = 1.97–10.77). The 186 base pair allele was also significantly associated with PD (OR = 1.85; p = 0.048; 95% CI = 1.01–3.42). The GT repeat in intron 2 of the MAOB gene is a powerful marker for PD in this large Australian cohort.

Url:

https://api.istex.fr/document/FDD5114F53B156A6821233554272A90BD578696A/fulltext/pdf

DOI: 10.1002/1531-8257(199903)14:2<219::AID-MDS1003>3.0.CO;2-9

Affiliations:

Australie

Le document en format XML

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<term>Case-Control Studies</term>
<term>Cohort Studies</term>
<term>Dinucleotide Repeats</term>
<term>Female</term>
<term>Gene</term>
<term>Gene Dosage</term>
<term>Genetics</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Monoamine Oxidase (genetics)</term>
<term>Monoamine oxidase B</term>
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<term>Parkinson disease</term>
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<front><div type="abstract" xml:lang="en">The monoamine oxidase B gene (MAOB; Xp15.21‐4) is a candidate gene for Parkinson's disease (PD) given its role in dopamine metabolism and its possible role in the activation of neurotoxins. The association of MAOB polymorphisms (a [GT] repeat allelic variation in intron 2 and an A–G transition in intron 13) with Parkinson's disease (PD) was studied in an Australian cohort of 204 (male:female ratio 1.60) people with PD and 285 (male:female ratio 1.64) age‐ and gender‐matched control subjects. Genomic DNA was extracted from venous blood and polymerase chain reaction was used to amplify the appropriate regions of the MAOB gene. The length of each (GT) repeat sequence was determined by 5% polyacrylamide denaturing gel electrophoresis and a DNA fragment analyzer, while the G–A genotype was determined using 2% agarose gel electrophoresis. The G–A polymorphism showed no association with PD (odds ratio [OR] = 0.80; p = 0.51; 95% confidence interval [CI] = 0.42–1.53). There was a significant difference in allele frequencies of the (GT) repeat allelic variation between patients and control subjects (χ2 = 20.09; p <0.01). After statistical adjustment for potential confounders using a logistic regression analysis, the (GT) repeat alleles ⩾188 base pairs in the intron 2 marker of the MAOB gene were significantly associated with PD (OR = 4.60; p <0.00005; 95% CI = 1.97–10.77). The 186 base pair allele was also significantly associated with PD (OR = 1.85; p = 0.048; 95% CI = 1.01–3.42). The GT repeat in intron 2 of the MAOB gene is a powerful marker for PD in this large Australian cohort.</div>
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Movement Disorders (revue)

Variations in the monoamine oxidase B lpar;MAOB) gene are associated with Parkinson's disease

Variations in the monoamine oxidase B lpar;MAOB) gene are associated with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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